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Pragmatic trials are studies designed to provide information for the practice of clinical trials in real life. They are typically characterized by a focus on the practical aspects of the study design, including recruitment and consent as well as adherence to the use of commonly available equipment.
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A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, that is crucial for pragmatic trials to be valid and to reduce bias in the results, is also necessary. However 프라그마틱 슬롯 무료 could cause issues with the design of the trial.
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The goal of pragmatic trials is to mimic real-life situations and achieve maximum validity externally. They are typically requested by practitioners and policymakers to inform their decisions. They can also be used to assess the cause-effect relationship of an intervention and its results. However, they shouldn't be used to substitute for explanation studies.
The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis and pragmatic trials, which guide the practice and policy decisions. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool was designed to define the elements of a pragmatic study that include the recruitment process, the design and delivery of the intervention, as well as follow-up.
There is a growing trend in the number of pragmatic trials that have been published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This is an indication that the health sciences community is becoming increasingly sensitized to the issue of pragmatism. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.